The lactic acid bacteria are gaining more attention as probiotics, because they are generally recognized as safe for consumption. The lactic acid bacteria are commercially very important group of bacteria and have a lot of positive impact on the health of host. The literature studies showed that the lactic acid bacteria exert positive impact on the health to modulate the immune response and protect the host against enteric pathogenic microbes. The lactic acid bacteria enhanced the secretion of IgA and improved the activity of macrophages and T cells. These, also, enhanced the production of interferon’s expression. In short, the consumption of lactic acid bacteria in food modulates the immune system by the secretion of IgA, prevents enteric infectious microbes, and improves the activity of interferon and interleukins.

Keywords: – Immune system, lactic acid bacteria, probiotic, mucosal immunity