Ling Li¹*, Biyan Zhang¹, Dong Li¹, Yunhui Yu¹, Fei Yang¹, Minjie Zhang¹, Zijun Chen^3, Yunsen Li², Yu Cao¹

¹Suzhou Pharmavan Co., Ltd, Suzhou, People’s Republic of China

²School of Institutes of Biology and Medical Sciences, Soochow University, Suzhou, People’s Republic of China

³School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China

 

*Corresponding author’s email: pharmanal@pharmavan.cn

Received: 12 September 2024 / Accepted: 10 December 2024 / Published Online: 23 January 2025

 

Abstract

 

With societal advancements, improved living standards, and an increased focus on product safety, cosmetics with natural ingredients have gained substantial public interest. Isodonis Japonicus (Isodon amethystoides (Benth.) H. Hara), a traditional Chinese herbal medicine, exhibits a broad spectrum of pharmacological activities. The leaves and stalks of Isodonis Japonicus (XCC), effectively inhibit the proliferation of C. acnes, thereby contributing to the balance of skin microecology. QPCR and ELISA results indicate significant suppression of the secretion of inflammatory factors by XCC. Additionally, XCC mitigates free radical damage through the downregulation of ROS expression and exhibits soothing and anti-allergic properties by lowering mast cell counts, as well as IgE expression, pruritus, and ear swelling. These results indicate that XCC possesses remarkable antibacterial, anti-inflammatory, antioxidant, and anti-allergy properties. In conclusion, this study comprehensively investigates the pharmacological activities of XCC from multiple perspectives, elucidating its potential applications in skincare and the treatment of skin diseases.

 

Keywords: XCC extract, Antibacterial, Anti-inflammatory, Anti-allergy, Antioxidant

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