1Department of Pharmacology, Al-Nafees Medical College, Isra University, Islamabad, Pakistan, 2Department of Pathology, Bakhtawar Amin Medical and Dental College, Multan, Pakistan, 3Department of Pathobiology, University College of Veterinary and Animal Sciences, The Islamia University, Bahawalpur, Pakistan, 4Department of Pathology, Al-Nafees Medical College, Isra University, Islamabad, Pakistan
ABSTRACT
The objective of this study was to assess the antihyperlipidemic efficacy of cinnamon powder in albino rats. For this purpose 180 adult albino rats (average weight 210 ± 11 grams) were purchased and divided into six groups. In rats blood lipid profile was raised using cholesterol @ 400mg/Kg body weight of rat which was mixed into rat feed for first 15 days of the study. Cinnamon bark powder equivalent to 1gm/kg, 2gm/kg, 4gm/kg and 6gm/kg was administered to the rats of treatment groups 15-60 days. Treatment control group was given Simvastatin at the dose rate of 0.6mg/Kg body weight. Blood samples were collected at 0, 15, 30, 45 and 60 days in sterilized gel tubes by direct heart puncturing. Serum was separated and analyzed for lipid profile parameters using reagent kits. Findings of present study revealed that various doses of Cinnamomum cassiae powder improved the serum lipid profile in albino rats by reducing Total Lipids, Total Cholesterol, Triglycerides and LDL cholesterol and increasing HDL cholesterol levels in cinnamon treated groups. Furthermore, the most significant effect was shown by 6 mg/kg dose level. From the results of the present study, it was concluded that Cinnamon powder has curative effect against hyperlipidemia.
