Yufan Gao1,2,3,4†, Yourong Ye1,2,3,4†, Fuzhou Liu1,2,3,4, Haiyang Li1,2,3,4, Lv Luo1,2,3,4, Hongliang Zhang1,2,3,4, Yangzom Chamba1,2,3,4, Peng Shang1,2,3,4*
1College of Animal Science, Xizang Agriculture and Animal Husbandry University, Linzhi 860000, Xizang, China
2Key Laboratory of Tibetan Pig Genetic Improvement and Reproduction Engineering, Linzhi 860000, Xizang, China
3Tibetan Pig Science and Technology Courtyard in Nyingchi, Linzhi 860000, Xizang, China
4The Provincial and Ministerial Co-founded Collaborative Innovation Center for R & D in Tibet Characteristic Agricultural and Animal Husbandry Resources, Linzhi 860000, Xizang, China
*Corresponding author’s email: nemoshpmh@126.com
†These authors contributed equally to this work
Received: 12 September 2025 / Revised: 13 December 2025 / Accepted: 19 December 2025 / Published Online: 29 January 2026
Abstract
Abnormalities in glycolipid metabolism are important health problems faced in livestock and poultry farming, which can lead to growth retardation, decreased production performance and multi-organ complications. Hyperoside (HYP) is a natural flavonoid compound found in various plants such as Forsythia pinnata, Forsythia suspensa, and Cuscuta chinensis. Medical studies have revealed that HYP exhibits a wide range of biological activities, including anticancer, anti-inflammatory, antibacterial, antiviral, antidepressant, and organ-protective effects. It is worth noting that HYP has demonstrated the intervention potential of multi-target and multi-pathway in the regulation of glycolipid metabolism. This paper systematically reviews its effects on glycolipid metabolism and related core molecular mechanisms by regulating carbohydrate absorption, improving insulin sensitivity, and protecting target organs such as the kidneys and liver. Additionally, this paper explores the potential of fibronectin type III domain-containing protein 5 (FNDC5) as a target for HYP to regulate glycolipid metabolism and thus influence meat quality, providing a theoretical basis for its development as a green feed additive and application in the livestock industry.
Keywords: Hyperoside, Glycolipid metabolism, Signaling pathway, Livestock production
